N,N-Dimethylformamide dimethyl acetal CAS No.4637-24-5

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CAS No.4637-24-5

Category	Details
Chemical Name	N,N-Dimethylformamide dimethyl acetal
CAS Number	4637-24-5
Other Names	DMF-DMA; 1.1-Dimethoxytrimethylamine; N,N-Dimethylformamide dimethyl ether, etc.
Molecular Formula	C5H13NO2
Molecular Weight	119.16 g/mol
Appearance	Colorless to white liquid
Melting Point	-85°C
Boiling Point	102-103°C (720 mmHg)
Density	0.897 g/mL at 25°C
Refractive Index	1.396 (lit.)
Flash Point	45°F (-7.22°C)
Solubility	Miscible with most organic solvents
Uses	Important intermediate in the synthesis of heterocyclic compounds; serves as a methylating agent and esterification dehydration agent; widely used in pharmaceutical synthesis, particularly in the synthesis of drugs like oxafloxacin, milrinone, and allopurinol.
Synthesis Method	Typically synthesized by reacting N,N-dimethylformamide with dimethyl sulfate to form an imine complex, which is then reacted with solid sodium methoxide dispersed in an organic solvent such as isoparaffins, solvent oil, or white oil.
Safety Information	May cause irritation to skin and eyes; handle in a well-ventilated area; avoid contact with ignition sources; store below +30°C; in case of contact, rinse with plenty of water and seek medical attention if necessary.

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