(R)-3-(Boc-Amino)piperidine

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CAS Number: 309956-78-3.

Molecular Formula: C10H20N2O2.

Molecular Weight: 200.28.

Appearance: White crystalline powder.

Boiling Point: 304.8°C at 760 mmHg.

Attribute	Details
Chemical Name	(R)-3-(Boc-Amino)piperidine
CAS Number	309956-78-3
Synonyms	(R)-3-Boc-Aminopiperidine; (R)-3-tert-Butoxycarbonylaminopiperidine; tert-butyl (3R)-piperidin-3-ylcarbamate; (R)-3-N-BOC-AMINO-PIPERIDINE
Formula	C10H20N2O2
Molecular Weight	200.28 g/mol
Appearance	White to off-white solid
Melting Point	121.0 to 125.0 °C
Boiling Point	304.8°C at 760 mmHg
Density	1.02 g/cm³
Solubility	Poorly soluble in water, but soluble in alcoholic organic solvents such as methanol and ethanol
Optical Activity	[α]22/D +3.2°, c = 0.5 in DMF
pKa	12.37±0.20 (Predicted)
Usage	Used as an intermediate in organic synthesis and pharmaceutical chemistry, particularly for the synthesis and modification of drug molecules and biologically active molecules. It is a key intermediate in the synthesis of drugs like Linagliptin and Alogliptin, which are inhibitors of dipeptidyl peptidase-4 (DPP-4) used for lowering blood glucose levels.
Safety Information	Xi, N; R37/38-41-50; Keep away from heat, sparks, and open flames. Avoid contact with skin and eyes. In case of contact, rinse immediately with plenty of water and seek medical advice.
Supplier	Various companies such as E’meishan Hongsen Biomedicine Co., Ltd., Chongqing Inskay Pharmaceutical Co., Ltd., Shandong Sihuan Pharmaceutical Co., Ltd., and Anqing Qichuang Pharmaceutical Co., Ltd.

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