Introduction to 4.4′-Dihydroxy-3.3′,5.5′-Tetramethyl-Biphenyl

4.4′-Dihydroxy-3.3′,5.5′-tetramethyl-biphenyl is a specialized chemical compound used in various industrial applications, particularly as an intermediate in the synthesis of high-performance polymers and specialty chemicals. This article provides a comprehensive overview of its chemical properties, applications, and safety considerations.

Chemical Properties

4.4′-Dihydroxy-3.3′,5.5′-tetramethyl-biphenyl is a white crystalline solid with a high melting point of 115-117°C. It is slightly soluble in water but readily soluble in organic solvents such as ethanol, acetone, and dimethylformamide (DMF). Its chemical structure consists of two hydroxyphenyl groups linked by a biphenyl bridge, with four methyl groups providing additional steric bulk and stability.

Applications

1. Polymer Synthesis

4.4′-Dihydroxy-3.3′,5.5′-tetramethyl-biphenyl is a key intermediate in the synthesis of high-performance polymers such as polyetheretherketone (PEEK) and polyphenylene sulfone (PPSU). These polymers are known for their excellent thermal stability, mechanical strength, and chemical resistance, making them ideal for demanding applications in aerospace, automotive, and electronics.

2. Specialty Chemicals

In the production of specialty chemicals, 4.4′-dihydroxy-3.3′,5.5′-tetramethyl-biphenyl is used as a starting material for the synthesis of various dyes, pigments, and other advanced materials. Its unique structure and functional groups make it a valuable component in the development of new compounds.

3. Pharmaceuticals

In the pharmaceutical industry, 4.4′-dihydroxy-3.3′,5.5′-tetramethyl-biphenyl is used as a starting material for the synthesis of various drugs and active pharmaceutical ingredients. Its reactivity and functional group versatility make it a valuable tool in the development of new medications.

Safety and Handling

4.4′-Dihydroxy-3.3′,5.5′-tetramethyl-biphenyl is classified as a hazardous substance with the following hazard statements:

H302: Harmful if swallowed.

H315: Causes skin irritation.

H319: Causes serious eye irritation.

Precautionary Statements:

P261: Avoid breathing dust/fume/gas/mist/vapors/spray.

P280: Wear protective gloves/protective clothing/eye protection/face protection.

P305 + P351 + P338: If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.

P333 + P313: If skin irritation or rash occurs: Get medical advice/attention.

Conclusion

4.4′-Dihydroxy-3.3′,5.5′-tetramethyl-biphenyl is a versatile and high-performance chemical compound with a wide range of applications in polymer synthesis, specialty chemicals, and pharmaceuticals. Its unique properties make it an essential component in the development of advanced materials and chemical processes. Proper handling and safety measures are crucial to ensure its safe and effective use.